GRIK4 anticorps (C-Term)

N° du produit ABIN499928

Détail du produit anti-GRIK4 anticorps

Antigène: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Épitope: C-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRIK4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: Grik4 antibody was raised against a 19 amino acid peptide near the carboxy terminus of the human Grik4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 0.5 - 1 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Détails sur GRIK4

Antigène: GRIK4 (Glutamate Receptor, Ionotropic, Kainate 4 (GRIK4))

Autre désignation: Glutamate Receptor KA1 / GRIK4 (GRIK4 Produits)

Synonymes: anticorps GRIK4, anticorps ka1, anticorps eaa1, anticorps EAA1, anticorps GRIK, anticorps GluK4, anticorps KA1, anticorps 6330551K01Rik, anticorps GluRgamma1, anticorps KA-1, anticorps glutamate receptor, ionotropic, kainate 4, anticorps glutamate ionotropic receptor kainate type subunit 4, anticorps glutamate receptor, ionotropic, kainate 4 L homeolog, anticorps grik4, anticorps GRIK4, anticorps grik4.L, anticorps Grik4

Sujet: Grik4 codes for the KA1 subunit of kainate-type ionotropic glutamate receptors which are critical regulators of network activity that act by modifying neuronal excitability, directly and indirectly, through GABAergic interneurons. Five subunits can assemble to form kainate receptors (KARs): GluR5 (coded by Grik1), GluR6 (coded by Grik2), and GluR7 (coded by Grik3) are the low-affinity subunits, and KA1 and KA2 are the high-affinity subunits. In the adult brain, KARs are located pre- and postsynaptically on pyramidal cells and on interneurons. Kainate receptors on GABA-containing interneurons enhance GABA release and thereby downregulate glutamatergic signaling. KARs have been implicated in numerous psychiatric disorders. Case control studies show significant association of Grik4 with both schizophrenia and bipolar disorder. Despite its predicted molecular weight, Grik4 often migrates at a lower molecular weight in SDS-PAGE.Synonyms: EAA1, Excitatory amino acid receptor 1, Glutamate receptor ionotropic kainate 4

ID gène: 2900

UniProt: Q16099

Pathways: Synaptic Membrane