HAAO anticorps (N-Term)

N° du produit ABIN499940

Détail du produit anti-HAAO anticorps

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HAAO est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Purification: Affinity chromatography purified via peptide column

Immunogène: HAAO antibody was raised against a 17 amino acid peptide near the amino terminus of human HAAO.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur HAAO

Antigène: HAAO (3-hydroxyanthranilate 3,4-Dioxygenase (HAAO))

Autre désignation: HAAO (HAAO Produits)

Synonymes: anticorps Afu2g17450, anticorps 0610007K21Rik, anticorps 0610012J07Rik, anticorps 3-HAO, anticorps 3-HAOxase, anticorps 3HAO, anticorps zgc:103585, anticorps HAO, anticorps 3-hydroxyanthranilate 3,4-dioxygenase, anticorps 3-hydroxyanthranilate 3,4-dioxygenase L homeolog, anticorps SPO1774, anticorps CNB05620, anticorps AFUA_2G17450, anticorps Bcep18194_C7641, anticorps Kfla_5491, anticorps Micau_4935, anticorps RBRH_03005, anticorps Krodi_1278, anticorps haao, anticorps HAAO, anticorps Haao, anticorps haao.L

Sujet: HAAO (3-Hydroxyanthranilate 3,4-dioxygenase) is a monomeric cytosolic protein of the family of intramolecular dioxygenases containing non-heme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is present in low amounts in the central nervous system. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurological and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. Furthermore, recent study shows that HAAO are excellent candidate biomarkers for detecting ovarian cancer.Synonyms: 3-HAO, 3-hydroxyanthranilate 3, 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid dioxygenase, 4-dioxygenase, HAD

ID gène: 23498

NCBI Accession: NP_036337

UniProt: P46952