INSM1 anticorps (N-Term)

N° du produit ABIN499952

Détail du produit anti-INSM1 anticorps

Antigène: INSM1 (Insulinoma-Associated 1 (INSM1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp INSM1 est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificité: This antibody reacts to IA-1.

Purification: Affinity chromatography purified via peptide column

Immunogène: IA-1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human IA-1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western Blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Store the antibody undiluted at 2-8 °C.

Détails sur INSM1

Antigène: INSM1 (Insulinoma-Associated 1 (INSM1))

Autre désignation: INSM1 / IA1 (INSM1 Produits)

Synonymes: anticorps IA-1, anticorps IA1, anticorps INSM-1, anticorps Insm1, anticorps fc13a09, anticorps wu:fc13a09, anticorps zINSM-1, anticorps zgc:63866, anticorps INSM1, anticorps ia-1, anticorps zgc:77257, anticorps INSM transcriptional repressor 1, anticorps insulinoma-associated 1, anticorps insulinoma-associated 1b, anticorps insulinoma associated 1, anticorps insulinoma associated 1 L homeolog, anticorps insulinoma-associated 1a, anticorps INSM1, anticorps Insm1, anticorps insm1b, anticorps insm1, anticorps insm1.L, anticorps insm1a

Sujet: IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100 % of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.Synonyms: Insulinoma-associated protein 1, Zinc finger protein IA-1

ID gène: 3642

NCBI Accession: NP_002187

UniProt: Q01101