CLCNKB anticorps (AA 51-150) (AbBy Fluor® 680)

N° du produit ABIN5000179

Détail du produit anti-CLCNKB anticorps (AbBy Fluor® 680)

Antigène: CLCNKB (Chloride Channel Kb (CLCNKB))

Épitope: AA 51-150

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CLCNKB est conjugé à/à la AbBy Fluor® 680

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human CLCNKB

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur CLCNKB

Antigène: CLCNKB (Chloride Channel Kb (CLCNKB))

Autre désignation: CLCNKB (CLCNKB Produits)

Synonymes: anticorps CLCNKA, anticorps CLCNKB, anticorps DKFZp469N0132, anticorps CLCKB, anticorps Clc-Ka, anticorps Clck2, anticorps Clcnk1l, anticorps ClC-K2L, anticorps ClC-K2, anticorps ClC-Kb, anticorps ClC-k, anticorps clc-kb, anticorps clckb, anticorps clcnka-A, anticorps clk-k2, anticorps x6clck, anticorps xCIC-K, anticorps xClC-K, anticorps zgc:64141, anticorps Clcnkb, anticorps chloride voltage-gated channel Kb, anticorps chloride channel Kb, anticorps chloride channel, voltage-sensitive Kb, anticorps chloride channel, voltage-sensitive Kb L homeolog, anticorps chloride channel K, anticorps chloride channel protein ClC-Ka, anticorps chloride channel protein ClC-Kb, anticorps CLCNKB, anticorps Clcnkb, anticorps clcnkb.L, anticorps clcnk, anticorps LOC100017912, anticorps LOC100400180, anticorps LOC100590605, anticorps LOC100730738

Sujet:

Synonyms: Bartter syndrome type 3, Chloride channel Kb, Chloride channel kidney B, Chloride channel protein ClC-Kb, Chloride channel voltage sensitive Kb, ClC K2, ClC-K2, ClCK2, CLCKB, CLCKB_HUMAN, CLCNKB, hClC Kb, hClCKb, MGC24087, OTTHUMP00000011120, OTTHUMP00000011121, RP11 5P18.8.

Background: The family of voltage-dependent chloride channels (CLCs) regulate cellular trafficking of chloride ions, a critical component of all living cells. CLCs regulate excitability in muscle and nerve cells, aid in organic solute transport, and maintain cellular volume. CLC-KA is a kidney-specific chloride channel that mediates transepithelial chloride transport in the thin ascending limb of the Henle loop in the inner medulla. CLC-KA plays a crucial role in urine concentration. The gene encoding human CLC-KA maps to chromosome 1p36. Mutations in this gene may be associated with nephrogenic diabetes insipidus in those cases where mutations in the vasopressin V2 receptor and the AQP2 water channel are lacking. CLC-KB mediates basolateral chloride ion efflux in the thick ascending limb and in more distal nephron segments. The gene encoding human CLC-KB maps to chromosome 1p36. Mutations in this gene cause type III Barter?s syndrome which is characterized by renal salt-wasting and low blood pressure.