COPS4 anticorps (AbBy Fluor® 750)

N° du produit ABIN5000406

Détail du produit anti-COPS4 anticorps (AbBy Fluor® 750)

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp COPS4 est conjugé à/à la AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human COPS4

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur COPS4

Antigène: COPS4 (COP9 Signalosome Subunit 4 (COPS4))

Autre désignation: COPS4 (COPS4 Produits)

Synonymes: anticorps CG8725, anticorps CH4, anticorps Cops4, anticorps Csn4, anticorps DCH4, anticorps Dch4, anticorps Dmel\\CG8725, anticorps csn4, anticorps l(2)k08018, anticorps COPS4, anticorps SGN4, anticorps DKFZp459H0324, anticorps AW208976, anticorps D5Ertd774e, anticorps fc90c08, anticorps wu:fc90c08, anticorps zgc:77137, anticorps ATS4, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 14, anticorps CONSTITUTIVE PHOTOMORPHOGENIC 8, anticorps COP14, anticorps COP9 SIGNALOSOME SUBUNIT 4, anticorps CSN4, anticorps EMB134, anticorps EMBRYO DEFECTIVE 134, anticorps FUS4, anticorps FUS8, anticorps FUSCA 4, anticorps FUSCA 8, anticorps MBD2.17, anticorps MBD2_17, anticorps COS41.8, anticorps COP9 signalosome subunit 4, anticorps COP9 signalosome complex subunit 4, anticorps COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis), anticorps Proteasome component (PCI) domain protein, anticorps COP9 signalosome subunit 4 L homeolog, anticorps CSN4, anticorps COPS4, anticorps CpipJ_CPIJ000966, anticorps csn4, anticorps Cops4, anticorps cops4, anticorps COP8, anticorps cops4.L, anticorps csn-4

Sujet:

Synonyms: CH4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 complex homolog subunit 4, COP9 complex S4, COP9 constitutive photomorphogenic homolog subunit 4, COP9 signalosome complex subunit 4, COP9 signalosome subunit 4, COPS4, CSN complex subunit 4, CSN4, CSN4 SCHPO, CSN4_HUMAN, DCH4, JAB1 containing signalosome subunit 4, JAB1-containing signalosome subunit 4, MGC94896, SGN4, Signalosome subunit 4.

Background: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

ID gène: 51138

Pathways: Cycle Cellulaire