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ERN1 anticorps (N-Term)

ERN1 Reactivité: Humain, Souris, Rat WB, IF, EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500050
  • Antigène Voir toutes ERN1 Anticorps
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Épitope
    • 16
    • 16
    • 15
    • 10
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 100
    • 76
    • 72
    • 16
    • 1
    Humain, Souris, Rat
    Hôte
    • 103
    • 5
    • 3
    • 1
    Lapin
    Clonalité
    • 106
    • 6
    Polyclonal
    Conjugué
    • 30
    • 11
    • 10
    • 6
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp ERN1 est non-conjugé
    Application
    • 79
    • 45
    • 30
    • 26
    • 26
    • 9
    • 9
    • 8
    • 6
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
    Specificité
    IRE1p antibody was raised against a 15 amino acid peptide from near the amino terminus of human IRE1p.
    Purification
    Affinity chromatography purified via peptide column
    Immunogène
    Human IRE1p (N-Terminus) Peptide
    Isotype
    IgG
    Top Product
    Discover our top product ERN1 Anticorps primaire
  • Indications d'application
    ELISA. Western Blot: 1 - 2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    ERN1 (Endoplasmic Reticulum To Nucleus Signaling 1 (ERN1))
    Autre désignation
    ERN1 / IRE1 (ERN1 Produits)
    Synonymes
    anticorps IRE1, anticorps IRE1P, anticorps IRE1a, anticorps hIRE1p, anticorps 9030414B18Rik, anticorps AI225830, anticorps C85377, anticorps Ire1a, anticorps Ire1alpha, anticorps Ire1p, anticorps RGD1559716, anticorps Ern1, anticorps Ire1, anticorps Ire1b, anticorps sb:eu1005, anticorps zgc:109932, anticorps endoplasmic reticulum to nucleus signaling 1, anticorps endoplasmic reticulum to nucleus signaling 2, anticorps endoplasmic reticulum (ER) to nucleus signalling 1, anticorps serine/threonine-protein kinase/endoribonuclease IRE1, anticorps endoplasmic reticulum (ER) to nucleus signalling 2, anticorps ERN1, anticorps ERN2, anticorps Ern1, anticorps LOC524719, anticorps Ern2, anticorps ern1
    Sujet
    Accumulation of malfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and the upregulation of the ER molecular chaperones GRP78 and GRP 94 (1,2). These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 (3,4) but ER stress causes their dissociation. This allows IRE1p, a serine-threonine protein kinase to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also has an endoribonuclease activity that is required to splice X-box binding protein (XBP1) mRNA converting it to a potent UPR transcriptional activation (5). Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER (6). Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, IRE1p, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1
    ID gène
    2081
    UniProt
    O75460
    Pathways
    ER-Nucleus Signaling, Unfolded Protein Response
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