IRGM anticorps (Center)
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- Antigène Voir toutes IRGM Anticorps
- IRGM (Immunity-Related GTPase Family, M (IRGM))
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Épitope
- Center
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IRGM est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects IRGM at center.
- Purification
- Peptide affinity chromatography
- Immunogène
- IRGM antibody was raised against a 14 amino acid peptide near the center of the human IRGM.
- Isotype
- IgG
- Top Product
- Discover our top product IRGM Anticorps primaire
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- Indications d'application
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ELISA: Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- IRGM (Immunity-Related GTPase Family, M (IRGM))
- Autre désignation
- IRGM / LRG-47 (IRGM Produits)
- Synonymes
- anticorps Ifi1, anticorps Iigp3, anticorps Iipg3, anticorps Irgm, anticorps LRG-47, anticorps IFI1, anticorps IRGM1, anticorps LRG47, anticorps immunity-related GTPase family M member 1, anticorps immunity-related GTPase M, anticorps immunity related GTPase M, anticorps immunity-related GTPase family M protein, anticorps Irgm1, anticorps Irgm, anticorps IRGM, anticorps LOC481473
- Sujet
- Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Two of the strongest hits implicate genes IRGM and ATG16L1, which encode proteins thought to be critical to the autophagy pathway and being significantly associated with Crohn's disease. In mouse, IRGM belongs to a family of gamma-interferon-induced GTP-binding proteins of approximately 48 kDa. Murine IRGM induces autophagy and generates large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. Human IRGM is also involved in autophagy and plays a role in the control of intracellular pathogens and in the reduction of intracellular bacillary load.Synonyms: IFI1, IRGM1, Immunity-related GTPase family M protein, Immunity-related GTPase family M protein 1, Interferon-inducible protein 1, LRG47
- ID gène
- 345611
- UniProt
- F8VPC9
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