KDM4A anticorps (Center)

N° du produit ABIN500080

Détail du produit anti-KDM4A anticorps

Antigène: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KDM4A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects JMJD2A.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: JMJD2A antibody was raised against a 14 amino acid peptide from near the center of human JMJD2A.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur KDM4A

Antigène: KDM4A (Lysine (K)-Specific Demethylase 4A (KDM4A))

Autre désignation: JMJD2A / KDM4A (KDM4A Produits)

Synonymes: anticorps JMJD2A, anticorps JHDM3A, anticorps JMJD2, anticorps TDRD14A, anticorps D4Ertd222e, anticorps Jmjd2, anticorps Jmjd2a, anticorps mKIAA0677, anticorps lysine demethylase 4A, anticorps lysine-specific demethylase 4A, anticorps lysine (K)-specific demethylase 4A, anticorps KDM4A, anticorps LOC100228023, anticorps Kdm4a

Sujet: Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. The first member of this group, JMJD2A, is widely expressed in human tissues and cell lines and functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. JMJD2A can also form a complex with the androgen receptor (AR), a transcription factor that is pivotal for the development of prostate cancer. Overexpression of JMJD2A stimulates AR function and this stimulation is dependent on JMJD2A catalytic activity, suggesting that JMJD2A might be a critical protein with roles in cell proliferation and oncogenesis.Synonyms: JHDM3A, JMJD2, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, KIAA0677, Lysine-specific demethylase 4A

ID gène: 9682

UniProt: O75164

Pathways: L'effet Warburg