LGI4 anticorps (C-Term)
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- Antigène Voir toutes LGI4 Anticorps
- LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp LGI4 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects LGI4 at C-term (only the larger form). It is predicted to be specific to LGI4 and not recognize other LGI proteins.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Peptide affinity chromatography
- Immunogène
- LGI4 antibody was raised against a 17 amino acid peptide from near the carboxy terminus of human LGI4.
- Isotype
- IgG
- Top Product
- Discover our top product LGI4 Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 1 - 2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- LGI4 (Leucine-Rich Repeat LGI Family, Member 4 (LGI4))
- Autre désignation
- LGI4 (LGI4 Produits)
- Synonymes
- anticorps Lgil3, anticorps clp, anticorps LGIL3, anticorps leucine rich repeat LGI family member 4, anticorps leucine-rich repeat LGI family, member 4, anticorps LGI4, anticorps Lgi4
- Sujet
- The leucine-rich, glioma inactivated gene 4 (LGI4) is a member of the LGI family in which LGI1 is the exemplar. The LGI family consists of four of highly related proteins containing leucine-rich repeats (LRRs) which are highly similar to other transmembrane signaling molecules and receptors. LGI1 has been identified as a candidate tumor suppressor gene for glioma and plays a role in autodominant lateral temporal epilepsy (ADTLE), an epileptic syndrome characterized by focal seizures with predominant auditory symptoms. Despite its high homology with LGI1 and similar pattern of expression, mutations in LGI4 have not been found to be associated with ADTLE. However, the LGI4 gene is located in a region linked to benign familial infantile convulsions. Further study revealed that a GC-to-AT polymorphism was correlated with childhood absence epilepsy. Other studies showed that decreasing LGI4 expression in cultured cells inhibits myelination, indicating that LGI4 may play a role in neural development. Two isoforms of LGI4 are known to exist.Synonyms: LGI1-like protein 3, LGI4, LGIL3, Leucine-rich glioma-inactivated protein 4, Leucine-rich repeat LGI family member 4
- ID gène
- 163175
- UniProt
- Q8N135
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