SCARB2
Reactivité: Humain, Souris, Rat, Chien
WB, IHC, IF, IP, ICC
Hôte: Lapin
Polyclonal
unconjugated
Indications d'application
ELISA. Western blot. Immunohistochemistry on paraffin sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Antigène
SCARB2
(Scavenger Receptor Class B, Member 2 (SCARB2))
anticorps cd36l2, anticorps fi13c07, anticorps chunp6914, anticorps wu:fi13c07, anticorps SCARB2, anticorps scarb2, anticorps AMRF, anticorps CD36L2, anticorps EPM4, anticorps HLGP85, anticorps LGP85, anticorps LIMP-2, anticorps LIMPII, anticorps SR-BII, anticorps 9330185J12Rik, anticorps Cd36l2, anticorps MLGP85, anticorps LimpII, anticorps scavenger receptor class B, member 2a, anticorps scavenger receptor class B member 2, anticorps scavenger receptor class B, member 2, anticorps scarb2a, anticorps SCARB2, anticorps scarb2, anticorps Scarb2
Sujet
The lysosomal integral membrane protein 2 (LIMP2) is a heavily glycosylated type III transmembrane protein, the majority of which exists in the lumen of the lysosome and a cytoplasmic domain of approximately 20 amino acids. A deficiency of LIMP2 in mice causes uretic pelvic junction obstruction, deafness, and peripheral neuropathy associated with impaired vesicular trafficking and distribution of apically expressed proteins. More recently, LIMP2 was shown to act as a receptor to bind b-glucocerebrosidase, the enzyme defective in Gaucher disease, a lysosomal storage disorder. LIMP2-deficient mice showed missorted as well as secreted b-glucocerebrosidase, suggesting that LIMP2 also functions as the mannose-6-phosphate-independent trafficking receptor. Despite its predicted molecular weight, LIMP2 runs at approximately 80 - 85 kDa in SDS-PAGE.Synonyms: 85 kDa lysosomal membrane sialoglycoprotein, CD36 antigen-like 2, CD36L2, LGP85, LIMP II, LIMP2, LIMPII, Lysosome membrane protein 2, SR-BII, SRB2, Scavenger receptor class B member 2