Transportin 1 anticorps (N-Term)

N° du produit ABIN500230

Détail du produit anti-Transportin 1 anticorps

Antigène: Transportin 1 (TNPO1)

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Transportin 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects MIP1 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: MAPKAP1 antibody was raised against a 19 amino acid peptide from near the amino terminus of human MAPKAP1.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Transportin 1

Antigène: Transportin 1 (TNPO1)

Autre désignation: MIP1 (TNPO1 Produits)

Synonymes: anticorps IPO2, anticorps KPNB2, anticorps MIP, anticorps MIP1, anticorps TRN, anticorps TNPO1, anticorps AU021749, anticorps D13Ertd688e, anticorps Kpnb2, anticorps ATTRN1, anticorps F12A24.13, anticorps F12A24_13, anticorps TRANSPORTIN 1, anticorps transportin 1, anticorps DKFZp469O204, anticorps transportin 1, anticorps transportin-1, anticorps transportin 1 S homeolog, anticorps TNPO1, anticorps LOC738932, anticorps tnpo1, anticorps Tnpo1, anticorps tnpo1.S, anticorps TRN1

Sujet: MAPKAP1 was initially identified as the human homolog of S. pombe SIN1. Recent evidence has shown that it identical to Mip1, a protein that interacts with MEKK2, a member of the mitogen-activated protein kinase (MAPK) intracellular signaling network. MAPKAP1 is thought to prevent MEKK2 activation and dimerization by forming a complex with the inactive and non-phosphorylated MEKK2, thereby blocking the JNK1/2, ERK1/2, p38 and ERK5 MAPKs. MAPKAP1 has also been shown to play a role in the TOR signaling process, a pathway that is involved in controlling cell growth and proliferation in response to environmental cues such as nutrients, growth factors and hormones. Experiments showed that MAPKAP1 helped to maintain the TOR/rictor assembly but not the TOR/RAPTOR complex, which allowed specific phosphorylation of Akt, a kinase that is believed to couple the growth factor-PI3K signaling pathway to the nutrient-regulated TOR signaling pathway. Multiple alternatively spliced isoforms of MAPKAP1 have been identified.Synonyms: MAPKAP1, Mitogen-activated protein kinase 2-associated protein 1, SAPK-interacting protein 1, SIN1, Stress-activated map kinase-interacting protein 1, TORC2 subunit MAPKAP1, Target of rapamycin complex 2 subunit MAPKAP1, mSIN1

ID gène: 79109

NCBI Accession: NP_001006618

UniProt: Q9BPZ7

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Cellular Glucan Metabolic Process, Protein targeting to Nucleus, CXCR4-mediated Signaling Events