MC4R anticorps (N-Term)

N° du produit ABIN500250

Détail du produit anti-MC4R anticorps

Antigène: MC4R (Melanocortin 4 Receptor (MC4R))

Épitope: N-Term

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MC4R est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects MC4-R.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: MC4R antibody was raised against a 19 amino acid peptide near the amino terminus of human MC4R.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur MC4R

Antigène: MC4R (Melanocortin 4 Receptor (MC4R))

Autre désignation: MC4-R (MC4R Produits)

Synonymes: anticorps zMC4, anticorps si:dkey-151m6.62, anticorps mc4r, anticorps MC4R, anticorps LOC100218148, anticorps Mc4-r, anticorps melanocortin 4 receptor, anticorps mc4r, anticorps MC4R, anticorps Mc4r

Sujet: The melanocortin-4 receptor (MC4R) is a member of the superfamily of seven transmembrane G-protein coupled receptors that are involved in multiple signal transduction pathways including the cAMP and MAPK signaling pathways. It is thought that the melanocortin system modulates energy expenditure and insulin sensitivity, activation of the MC4R results in the inhibition of c-Jun N-terminal kinase (JNK) activity and promotes insulin signaling. MC4R-null mice display maturity onset obesity characterized by hyperphagia, increased adiposity, hyperinsulinaemia and hyperleptinaemia, suggesting that like other obesity-linked genes such as FTO, PTER, and NPC1, MC4R is a potential candidate target for the treatment of obesity.Synonyms: MC4R, Melanocortin receptor 4

ID gène: 4160

NCBI Accession: NP_005903

UniProt: P32245

Pathways: Hormone Transport, cAMP Metabolic Process, Feeding Behaviour