LY96 anticorps (Center)

N° du produit ABIN500262

Détail du produit anti-LY96 anticorps

Antigène: LY96 (Lymphocyte Antigen 96 (LY96))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LY96 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Ion exchange chromatography

Immunogène: MD-2 antibody was raised against a peptide corresponding to amino acids near the middle region of human MD-2.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 to 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur LY96

Antigène: LY96 (Lymphocyte Antigen 96 (LY96))

Autre désignation: MD-2 (LY96 Produits)

Synonymes: anticorps MD2, anticorps ESOP-1, anticorps MD-2, anticorps ly-96, anticorps Ly-96, anticorps Md2, anticorps lymphocyte antigen 96, anticorps LY96, anticorps Ly96

Sujet: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs) (1-3). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses (4). TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS (5,6). The specificity of this response is determined by the species of MD-2, e.g., human MD-2 can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4 (7).Synonyms: ESOP-1, ESOP1, LY96, Lymphocyte antigen 96, MD2

NCBI Accession: NP_056179

UniProt: Q9Y6Y9

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades