IFIH1 anticorps (Center)

N° du produit ABIN500266

Détail du produit anti-IFIH1 anticorps

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IFIH1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Helicard at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, Mouse

Purification: Peptide Affinity Chromatography

Immunogène: 16 amino acid peptide from near the center of Human MDA5.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Détails sur IFIH1

Antigène: IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Autre désignation: Helicard (IFIH1 Produits)

Synonymes: anticorps MDA5, anticorps Hlcd, anticorps IDDM19, anticorps MDA-5, anticorps RLR-2, anticorps 9130009C22Rik, anticorps Helicard, anticorps RGD1560496, anticorps interferon induced with helicase C domain 1, anticorps IFIH1, anticorps Ifih1

Sujet: The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF-kB. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.Synonyms: Helicase with 2 CARD domains, IFIH1, Interferon-induced helicase C domain-containing protein 1, MDA5, Melanoma differentiation-associated protein 5, Murabutide down-regulated protein, RH116, RNA helicase-DEAD box protein 116

ID gène: 64135

NCBI Accession: NP_071451

UniProt: Q9BYX4

Pathways: Activation of Innate immune Response