MTBP anticorps (Middle Region)

N° du produit ABIN500294

Détail du produit anti-MTBP anticorps

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Épitope: AA 122-139, Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MTBP est non-conjugé

Application: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunofluorescence (IF)

Specificité: This antibody detects MTBP at center.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: MTBP antibody was raised against a synthetic peptide corresponding to amino acids 122 to 139 of human MTBP, which differ from the mouse sequence by three amino acids (7).

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur MTBP

Antigène: MTBP (MDM2 Binding Protein (MTBP))

Autre désignation: MTBP (MTBP Produits)

Synonymes: anticorps MDM2BP, anticorps AI429604, anticorps MDM2 binding protein, anticorps Mdm2, transformed 3T3 cell double minute p53 binding protein, anticorps MTBP, anticorps Mtbp

Sujet: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2 , p53R2 (2), p53AIP1 (3), Noxa (4), PIDD (5), PID/MTA2 (6) and MTBP (7), were recently discovered. The transcriptional activity of p53 is modulated by posttranslational regulations of the p53 protein including stabilization and acetylation. P53 transcriptionally activates MDM2 gene then the translated MDM2 protein binds to p53 and promotes the degradation of p53 leading to lowering the concentration of p53 protein. MDM2 inhibits both p53 mediated G1 arrest and apoptosis. A recently discovered protein termed MTBP was found to bind to MDM2 and to inhibit the modulation effect of MDM2 on p53 (7). MTBP is expressed in a variety of normal tissues (7).Synonyms: Mdm2, Mdm2-binding protein, hMTBP

ID gène: 27085

NCBI Accession: NP_071328

UniProt: Q96DY7