GUCA1C anticorps (AA 141-209) (AbBy Fluor® 680)
-
- Antigène Voir toutes GUCA1C Anticorps
- GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
-
Épitope
- AA 141-209
- Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp GUCA1C est conjugé à/à la AbBy Fluor® 680
-
Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GCAP3
- Isotype
- IgG
- Top Product
- Discover our top product GUCA1C Anticorps primaire
-
-
- Indications d'application
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- GUCA1C (Guanylate Cyclase Activator 1C (GUCA1C))
- Autre désignation
- GCAP3 (GUCA1C Produits)
- Synonymes
- anticorps gcap3, anticorps GCAP3, anticorps guanylate cyclase activator 1C, anticorps guca1c, anticorps GUCA1C
- Sujet
-
Synonyms: GCAP 3, Guanylate cyclase activating photoreceptor 3, Guanylate cyclase activator 1C, Guanylyl cyclase activating protein 3, Guanylyl cyclase-activating protein 3, GUC1C_HUMAN, GUCA1C.
Background: The intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating proteins (GCAP). GCAPs are calcium-binding proteins belonging to the calmodulin superfamily and are specifically expressed in retina. GCAP3 (Guanylyl cyclase-activating protein 3), also known as GUCA1C (Guanylate cyclase activator 1C), is a 209 amino acid EF-hand calcium binding protein that is activated by the decrease in calcium from the absorption of light by rhodopsin. Activation of GCAP3 leads to stimulation of guanylate cyclase 1 and 2 (GC1 and GC2), which increases cGMP concentration. Calcium sensitive regulation of GC is essential in recovery of the rod receptor dark state following light exposure. There are two isoforms of GCAP3 that are produced as a result of alternative splicing events.
- ID gène
- 9626
- Pathways
- Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
-