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GLDN anticorps (AA 365-460) (AbBy Fluor® 750)

GLDN Reactivité: Humain, Souris, Rat WB, IF (p), IF (cc) Hôte: Lapin Polyclonal AbBy Fluor® 750
N° du produit ABIN5003536
  • Antigène Voir toutes GLDN Anticorps
    GLDN (Gliomedin (GLDN))
    Épitope
    • 14
    • 7
    • 6
    • 6
    • 6
    • 3
    • 1
    AA 365-460
    Reactivité
    • 35
    • 20
    • 20
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 34
    • 1
    Lapin
    Clonalité
    • 35
    Polyclonal
    Conjugué
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp GLDN est conjugé à/à la AbBy Fluor® 750
    Application
    • 35
    • 17
    • 12
    • 12
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
     Réactivité croisée
    Humain, Souris, Rat
    Homologie
    Dog,Cow,Sheep,Pig,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Gliomedin/COLM
    Isotype
    IgG
    Top Product
    Discover our top product GLDN Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    GLDN (Gliomedin (GLDN))
    Autre désignation
    Gliomedin (GLDN Produits)
    Synonymes
    anticorps CLOM, anticorps COLM, anticorps CRG-L2, anticorps CRGL2, anticorps UNC-112, anticorps Clom, anticorps Colm, anticorps Crgl2, anticorps Crlg2, anticorps gliomedin, anticorps GLDN, anticorps Gldn, anticorps gldn
    Sujet

    Synonyms: CANCER RELATED GENE LIVER 2, Cancer related gene-Liver 2, CLOM, collomin, Colm gene name, COLM, Colmedin, CRG L2, FLJ23917, Gldn gene name, UNC 112, GLDN_HUMAN.

    Background: Gliomedin is a 551 amino acid protein encoded by the human gene GLDN. Gliomedin is thought to play a role in the formation of the nodes of Ranvier along myelinated axons. Accumulation of Na+ channels at the nodes of Ranvier is a prerequisite for saltatory conduction. In peripheral nerves, clustering of these channels along the axolemma is regulated by myelinating Schwann cells through an unknown mechanism. Gliomedin is a glial ligand for Neurofascin and NrCAM, two axonal immunoglobulin cell adhesion molecules that are associated with Na+ channels at the nodes of Ranvier. Gliomedin is expressed by myelinating Schwann cells and accumulates at the edges of each myelin segment during development, where it aligns with the forming nodes. Gliomedin is a single-pass type II membrane protein localized to the nodes of Ranvier and is specifically expressed in spinal cord, brain, placenta and sciatic nerve. It is more abundant in peripheral than central nervous system.

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