TACR3 anticorps (Center)

N° du produit ABIN500361

Détail du produit anti-TACR3 anticorps

Antigène: TACR3 (Tachykinin Receptor 3 (TACR3))

Épitope: Center

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TACR3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Tachykinin receptor 3 (TACR3) at center. It does not recognize NK1R or NK2R.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: NK3R antibody was raised against a 18 amino acid peptide from near the center of human NK3R.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TACR3

Antigène: TACR3 (Tachykinin Receptor 3 (TACR3))

Abstract: TACR3 Produits

Synonymes: anticorps HH11, anticorps NK-3R, anticorps NK3R, anticorps NKR, anticorps TAC3RL, anticorps Nk3r, anticorps Nkr, anticorps Tac3r, anticorps Nmkr, anticorps tachykinin receptor 3, anticorps neuromedin-K receptor, anticorps TACR3, anticorps LOC100544805, anticorps Tacr3

Sujet: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B.Synonyms: NK-3 receptor, NK-3R, NK3R, NKR, Neurokinin B receptor, Neuromedin-K receptor, TAC3R

ID gène: 6870

NCBI Accession: NP_001050

UniProt: P29371

Pathways: Feeding Behaviour