mGluR1 + mGluR5 anticorps (AA 651-750) (AbBy Fluor® 680)
-
- Antigène Tous les produits mGluR1 + mGluR5 (mGluR1/5)
- mGluR1 + mGluR5 (mGluR1/5) (Glutamate Receptor, Metabotropic 5/1 (mGluR1/5))
-
Épitope
- AA 651-750
-
Reactivité
- Souris, Rat, Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp mGluR1 + mGluR5 est conjugé à/à la AbBy Fluor® 680
-
Application
- Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Humain, Souris, Rat
- Homologie
- Dog,Cow,Pig,Horse,Chicken
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human GRM1
- Isotype
- IgG
-
-
- Indications d'application
-
FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- mGluR1 + mGluR5 (mGluR1/5) (Glutamate Receptor, Metabotropic 5/1 (mGluR1/5))
- Autre désignation
- Group I mGLUR (mGluR1/5 Produits)
- Sujet
-
Synonyms: glutamate receptor metabotropic 1, Glutamate Receptor Metabotropic 1,Metabotropic glutamate receptor 1, mGluR1,MGLUR1, GRM1_HUMAN, MGLUR5, mGlur5, GRM5, GRM5_HUMAN.
Background: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms, some of which may have distinct functions. [provided by RefSeq].
- ID gène
- 2911, 2915
-