A synthetic peptide corresponding to 14 amino acids near the amino terminus of Human p53DINP1. .Remarks: This sequence is identical between apha and beta forms of the p53DINP1 proteins, and differs by one amino acid from those of Mouse.
TP53INP1
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
Biotin
Indications d'application
ELISA. Western blot (1-2 μg/mL). Human lung tissue lysate can be used as a Positive Control and a band at 27 kDa can bedetected. A lower band at 18 kDa was detected in Human spleen, and Mouse liver andkidney tissue lysates, which may represent the p53DINP1-beta form. Immunohistochemistry on Paraffin Sections (2 μg/mL). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % Sodium Azide as preservative.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C
Stockage commentaire
Store the antibody undiluted at 2-8 °C.
Ferrajoli, Ivan, Ciccone, Shimizu, Kita, Ohtsuka, DAbundo, Qiang, Lerner, Nouraee, Rabe, Rassenti, Van Roosbroeck, Manning, Yuan, Zhang, Shanafelt, Wierda, Sabbioni, Tarrand, Estrov, Radovich, Liang et al.: "Epstein-Barr Virus MicroRNAs are Expressed in Patients with Chronic Lymphocytic Leukemia and Correlate with Overall Survival. ..." dans: EBioMedicine, Vol. 2, Issue 6, pp. 572-82, (2016) (PubMed).
Antigène
TP53INP1
(Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
anticorps cb1036, anticorps wu:fb70a09, anticorps wu:fi13h08, anticorps zgc:158431, anticorps TP53INP1, anticorps 2700057G22Rik, anticorps SIP, anticorps SIP18, anticorps SIP27, anticorps Stinp, anticorps Teap, anticorps TP53DINP1, anticorps TP53INP1A, anticorps TP53INP1B, anticorps p53DINP1, anticorps Trp53inp1, anticorps tumor protein p53 inducible nuclear protein 1, anticorps tumor protein p53 inducible nuclear protein 1 S homeolog, anticorps transformation related protein 53 inducible nuclear protein 1, anticorps TP53INP1, anticorps tp53inp1.S, anticorps tp53inp1, anticorps Trp53inp1, anticorps Tp53inp1
Sujet
Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible gene was identified recently and designated p53DINP1 (for p53-dependent damage-inducible nuclear protein 1) and SIP (for stress induced protein) in human and mouse (1,2).?A p53DINP1 antisense oligonucleotide inhibits and overexpression of p53DINP1 enhances Ser46 phosphorylation of p53, induction of p53AIP1, and cell death induced by DNA double-strand breaks (1). p53DINP1 may regulate p53-dependent apoptosis through phosphorylation at Ser46 and induction of p53AIP1. The p53DINP1/SIP gene encodes two proteins of 27 and 18 kDa in human and mouse termed p53DINP1-a and p53DINP1-b or SIP27 and SIP18 (1,2). p53DINP1/SIP is expressed in many tissues and induced by a variety of stress agents including UV stress, mutagenic stress, heat shock, and oxidative stress (2).Synonyms: P53DINP1, SIP, Stress-induced protein, Tumor protein p53-inducible nuclear protein 1, p53-dependent damage-inducible nuclear protein 1, p53-inducible nuclear protein 1