PAK2 anticorps (N-Term)

N° du produit ABIN500441

Détail du produit anti-PAK2 anticorps

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PAK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects PAK2 at N-term.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: 14 amino acid peptide from near the amino terminus of human PAK2

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-PAK2 (ABIN500441)

Choi, Pease, Chen, Zhang, Phee: "P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells." dans: Immunology, Vol. 154, Issue 2, pp. 309-321, (2018) (PubMed).

Phee, Au-Yeung, Pryshchep, OHagan, Fairbairn, Radu, Kosoff, Mollenauer, Cheng, Chernoff, Weiss: "Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation." dans: eLife, Vol. 3, pp. e02270, (2015) (PubMed).

Détails sur PAK2

Antigène: PAK2 (P21-Activated Kinase 2 (PAK2))

Autre désignation: PAK2 (PAK2 Produits)

Synonymes: anticorps PAK65, anticorps PAKgamma, anticorps gamma-PAK, anticorps 5330420P17Rik, anticorps A130002K10Rik, anticorps AI836325, anticorps D16Ertd269e, anticorps PAK-2, anticorps mKIAA4182, anticorps pak2, anticorps cb422, anticorps kinase, anticorps zgc:91798, anticorps wu:fb71h01, anticorps si:dz198m22.1, anticorps pak65, anticorps pakgamma, anticorps PAKI, anticorps Pak3, anticorps CH73-159L23.1, anticorps wu:fc52b03, anticorps zgc:113857, anticorps p21 (RAC1) activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2, anticorps p21 protein (Cdc42/Rac)-activated kinase 2a, anticorps p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog, anticorps p21 protein (Cdc42/Rac)-activated kinase 2b, anticorps PAK2, anticorps Pak2, anticorps pak2a, anticorps pak2.S, anticorps pak2b

Sujet: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.Synonyms: Gamma-PAK, PAK 2, PAK gamma, PAK-2, PAK65, Serine/threonine-protein kinase PAK 2, p21-activated kinase 2, p58

ID gène: 5062

NCBI Accession: NP_002568

UniProt: Q13177

Pathways: Signalisation MAPK, Signalisation RTK, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha