anticorps 2900068C24Rik, anticorps Ddxbp1, anticorps GBP, anticorps DDXBP1, anticorps GU/RH-II, anticorps ZMIZ3, anticorps ddxbp1, anticorps gbp, anticorps pias, anticorps pias1-A, anticorps xPAIS1, anticorps xPIAS1, anticorps zmiz3, anticorps protein inhibitor of activated STAT 1, anticorps protein inhibitor of activated STAT, 1, anticorps protein inhibitor of activated STAT, 1a, anticorps protein inhibitor of activated STAT 1 L homeolog, anticorps PIAS1, anticorps Pias1, anticorps pias1a, anticorps pias1.L
Sujet
The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated ?-globin expression in erythroid cells.Synonyms: DDXBP1, DEAD/H box-binding protein 1, E3 SUMO-protein ligase PIAS1, Gu-binding protein, PIAS-1, Protein inhibitor of activated STAT protein 1, RNA helicase II-binding protein