IKAP/p150 anticorps (AA 1151-1250) (AbBy Fluor® 680)
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- Antigène Voir toutes IKAP/p150 (ELP1) Anticorps
- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
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Épitope
- AA 1151-1250
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Reactivité
- Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IKAP/p150 est conjugé à/à la AbBy Fluor® 680
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Application
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- Réactivité croisée
- Souris, Rat
- Homologie
- Human,Rabbit
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic peptide derived from human IKAP
- Isotype
- IgG
- Top Product
- Discover our top product ELP1 Anticorps primaire
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- Indications d'application
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
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- Antigène
- IKAP/p150 (ELP1) (Elongator Complex Protein 1 (ELP1))
- Autre désignation
- IKAP (ELP1 Produits)
- Synonymes
- anticorps DYS, anticorps ELP1, anticorps FD, anticorps IKAP, anticorps IKI3, anticorps TOT1, anticorps IKBKAP, anticorps DKFZp469N1415, anticorps 3110040G09Rik, anticorps 6030413P05, anticorps C78473, anticorps Elp1, anticorps Ikbkap, anticorps elongator complex protein 1, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein, anticorps ielongator complex protein 1 S homeolog, anticorps inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein, anticorps ELP1, anticorps Elp1, anticorps IKBKAP, anticorps elp1.S, anticorps elp1, anticorps Ikbkap
- Sujet
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Synonyms: DKFZp781H1425, DYS, Dysautonomia Riley Day syndrome hereditary sensory autonomic neuropathy type III, Elongator complex protein 1, ELP 1, ELP1, ELP1_HUMAN, FD, FLJ12497, IKAP, IkappaB kinase complex associated protein, IkappaB kinase complex-associated protein, ikbkap, IKI 3, IKI3, IKK complex associated protein, IKK complex-associated protein, Inhibitor of kappa light polypeptide gene enhancer in B cells kinase complex associated protein, OTTHUMP00000063889, p150, TOT 1, TOT1
Background: The transcription factor NFkB is retained in the cytoplasm in an inactive form by the inhibitory protein IkB. Activation of NFkB requires that IkB be phosphorylated on specific serine residues, which results in the targeted degradation of IkB (1). IkB kinase alpha (IKK alpha), previously designated CHUK (2), interacts with IkB-alpha and specifically phosphorylates IkB-alpha on the sites that trigger its degradation, serines 32 and 36 (3). IKKalpha appears to be critical for NFkB activation in response to proinflammatory cytokines (4). Phosphorylation of the IkB by IKK alpha is stimulated by the NFkB inducing kinase (NIK), which itself is a central regulator for NFkB activation in response to TNF and IL-1 (5). The functional IKK complex contains three subunits, IKK alpha, IKK beta and IKK gamma (also designated NEMO), and each appears to make essential contributions to IkB phosphorylation (6). IKAP (IKK-complex-associated protein) is a protein that acts as a scaffold, interacting with NIK, IKK alpha and IKK beta and assembling them into an active kinase complex (7,8)
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