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UIMC1 anticorps (N-Term)

UIMC1 Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500569
  • Antigène Voir toutes UIMC1 Anticorps
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Épitope
    • 6
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 31
    • 7
    • 5
    Humain, Souris
    Hôte
    • 28
    • 2
    • 1
    Lapin
    Clonalité
    • 31
    Polyclonal
    Conjugué
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp UIMC1 est non-conjugé
    Application
    • 18
    • 9
    • 6
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects UIMC1 / RAP80 at N-term.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    RAP80 antibody was raised against a 17 amino acid peptide from near the amino terminus of human RAP80.
    Isotype
    IgG
    Top Product
    Discover our top product UIMC1 Anticorps primaire
  • Indications d'application
    ELISA: Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    Autre désignation
    UIMC1 / RAP80 (UIMC1 Produits)
    Synonymes
    anticorps UIMC1, anticorps RAP80, anticorps X2HRIP110, anticorps 9430016E08Rik, anticorps D330018D10Rik, anticorps D630032M02Rik, anticorps RIP110, anticorps Rxrip110, anticorps RGD1307009, anticorps ubiquitin interaction motif containing 1, anticorps UIMC1, anticorps Uimc1
    Sujet
    RAP80 was initially identified as zinc-finger containing nuclear protein that is highly expressed in testis and interacts with the retinoid-related testis-associated receptor (RTR). Later experiments revealed that RAP80 is recruited by the Coiled-coil domain 98 (CCDC98) protein to the breast cancer-1 protein BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both RAP80 and CCDC98 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either RAP80 or CCDC98 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that RAP80 and CCDC98 control only part of the DNA damage response role of BRCA1. At least four isoforms of RAP80 are known to exist.Synonyms: BRCA1-A complex subunit RAP80, RXRIP110, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1
    ID gène
    51720
    UniProt
    Q96RL1
    Pathways
    Réparation de l'ADN, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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