RAPTOR anticorps (N-Term)

N° du produit ABIN500573

Détail du produit anti-RAPTOR anticorps

Antigène: RAPTOR

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAPTOR est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Specificité: This antibody detects RAPTOR at N-term. Raptor has multiple isoforms that may also be recognized by the antibody.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse

Purification: Peptide affinity chromatography

Immunogène: Raptor polyclonal antibody was raised against a 13 amino acid peptide from near the amino- terminus of human Raptor.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur RAPTOR

Antigène: RAPTOR

Autre désignation: RAPTOR (RAPTOR Produits)

Synonymes: anticorps KOG1, anticorps Mip1, anticorps 4932417H02Rik, anticorps Rap, anticorps Raptor, anticorps mKIAA1303, anticorps RGD1311784, anticorps regulatory associated protein of MTOR complex 1, anticorps regulatory associated protein of MTOR, complex 1, anticorps RPTOR, anticorps Rptor

Sujet: The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1). Rapamycin inhibits TOR activity resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation (reviewed in 2). Raptor (regulatory associated protein of TOR) is a TOR-binding protein essential for TOR signaling in vivo. It acts as a TOR scaffold protein whose binding by TOR substrates is necessary for effective TOR-catalyzed phosphorylation (3). These substrates include the ribosomal protein S6 kinase (RP S6K) and the eukaryotic initiation factor 4E binding protein 4EBP1, proteins necessary for cell growth and proliferation and responsive to nutrient and mitogen levels (4). Raptor binds these proteins through a common 5 amino acid TOR-signaling (TOS) motif, mutation of this motif prevents the TOR-dependent phosphorylation of these proteins (5).Synonyms: KIAA1303, P150 target of rapamycin TOR-scaffold protein, RPTOR, Regulatory-associated protein of mTOR

ID gène: 57521

UniProt: Q8N122

Pathways: L'effet Warburg