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SCO1 anticorps (Center)

SCO1 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500686
  • Antigène Voir toutes SCO1 Anticorps
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Épitope
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    • 15
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 12
    • 3
    Lapin
    Clonalité
    • 15
    Polyclonal
    Conjugué
    • 11
    • 2
    • 1
    • 1
    Cet anticorp SCO1 est non-conjugé
    Application
    • 10
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects SCO1 / SCOD1 (both isoforms). It has no cross-reactivity to SCO2.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    SCO1 antibody was raised against a 14 amino acid peptide from near the center of human SCO1.
    Isotype
    IgG
    Top Product
    Discover our top product SCO1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))
    Autre désignation
    SCO1 / SCOD1 (SCO1 Produits)
    Synonymes
    anticorps SCOD1, anticorps 2610001C07Rik, anticorps D11Bwg1310e, anticorps SCO1, anticorps RGD1559538, anticorps SCO1, cytochrome c oxidase assembly protein, anticorps SCO1 cytochrome c oxidase assembly protein, anticorps SCO1, anticorps Sco1, anticorps sco1
    Sujet
    Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding. Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function. It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase. At least two isoforms of SCO1 are known to exist.Synonyms: Protein SCO1 homolog mitochondrial
    ID gène
    6341
    UniProt
    O75880
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity
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