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SHoc2/Sur8 anticorps (N-Term)

SHOC2 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500706
  • Antigène Voir toutes SHoc2/Sur8 (SHOC2) Anticorps
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Épitope
    • 15
    • 13
    • 9
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 41
    • 27
    • 20
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 41
    Lapin
    Clonalité
    • 41
    Polyclonal
    Conjugué
    • 13
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SHoc2/Sur8 est non-conjugé
    Application
    • 37
    • 19
    • 13
    • 13
    • 5
    • 3
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects SHOC2.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    SHOC2 antibody was raised against a 21 amino acid peptide near the amino terminus of human SHOC2.
    Isotype
    IgG
    Top Product
    Discover our top product SHOC2 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1-2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C
    Stockage commentaire
    Store the antibody undiluted at 2-8 °C.
  • Antigène
    SHoc2/Sur8 (SHOC2) (Leucine-rich repeat protein SHOC-2 (SHOC2))
    Autre désignation
    SHOC2 (SHOC2 Produits)
    Synonymes
    anticorps AU017287, anticorps Sur8, anticorps mKIAA0862, anticorps SIAA0862, anticorps SOC2, anticorps SUR8, anticorps si:ch211-159c12.3, anticorps si:ch211-197i12.3, anticorps zgc:152956, anticorps soc-2 (suppressor of clear) homolog (C. elegans), anticorps SHOC2 leucine-rich repeat scaffold protein, anticorps SHOC2 leucine-rich repeat scaffold protein S homeolog, anticorps SHOC2, leucine rich repeat scaffold protein, anticorps Shoc2, anticorps shoc2.S, anticorps SHOC2, anticorps shoc2
    Sujet
    SHOC2 protein participates in protein binding / transferase activity in the fibroblast growth factor receptor signaling pathway and Ras protein signal transduction. It is a widely expressed protein composed almost entirely of leucine-rich repeats (LRR), with a lysine-rich sequence at the amino terminus and cytoplasmically localized. SHOC2 acts as a positive modulator of the RAS-MAPK signaling cascade, which is elicited by EGL-15 and LET-23 and mediated by LET-60. SHOC2 together with protein phosphatase 1c (PP1c) forms a highly specific M-Ras effector complex and is essential for activation of the MAPK pathway by growth factors. Furthermore, in tumor cells with Ras gene mutations, inhibition of SHOC2 expression inhibits MAPK, but not PI3K activity. The SHOC2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer. Recent studies show that aberrantly acquired N-myristoylation of SHOC2 causes human disease Noonan-like syndrome with loose anagen hair.Synonyms: KIAA0862, Leucine-rich repeat protein SHOC-2, Protein soc-2 homolog, Protein sur-8 homolog, SHOC-2, SOC2, SUR8
    ID gène
    8036
    NCBI Accession
    NP_031399
    UniProt
    Q9UQ13
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