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MTMR14 anticorps (AA 161-260) (AbBy Fluor® 680)

MTMR14 Reactivité: Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 680
N° du produit ABIN5007108
  • Antigène Voir toutes MTMR14 Anticorps
    MTMR14 (Myotubularin Related Protein 14 (MTMR14))
    Épitope
    • 14
    • 8
    • 7
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 161-260
    Reactivité
    • 31
    • 19
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris
    Hôte
    • 39
    • 7
    Lapin
    Clonalité
    • 41
    • 5
    Polyclonal
    Conjugué
    • 23
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MTMR14 est conjugé à/à la AbBy Fluor® 680
    Application
    • 43
    • 22
    • 12
    • 12
    • 7
    • 5
    • 5
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human MTMR14
    Isotype
    IgG
    Top Product
    Discover our top product MTMR14 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    MTMR14 (Myotubularin Related Protein 14 (MTMR14))
    Autre désignation
    MTMR14 (MTMR14 Produits)
    Synonymes
    anticorps fc14d11, anticorps wu:fc14d11, anticorps MGC131146, anticorps C3orf29, anticorps 1110061O04Rik, anticorps AW553738, anticorps C76151, anticorps RGD1304842, anticorps jumpy, anticorps myotubularin related protein 14, anticorps myotubularin-related protein 14, anticorps myotubularin related protein 14 S homeolog, anticorps mtmr14, anticorps LOC703936, anticorps mtmr14.S, anticorps MTMR14, anticorps Mtmr14
    Sujet

    Synonyms: C3orf29, Egg derived tyrosine phosphatase homolog, FLJ11546, FLJ22405, FLJ46453, FLJ90311, HCV NS5A transactivated protein 4 splice variant A binding protein 1, HCV NS5A-transactivated protein 4 splice variant A-binding protein 1, hJumpy, jumpy, MTMR 14, MTMR14, MTMR-14, MTMRE_HUMAN, Myotubularin related protein 14, Myotubularin-related protein 14, NS5ATP4ABP1.

    Background: Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).

    Pathways
    Inositol Metabolic Process
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