SLC22A17
Reactivité: Humain, Rat
WB, IF (cc), IF (p)
Hôte: Lapin
Polyclonal
AbBy Fluor® 594
Indications d'application
ELISA. Western blot: 1 μg/mL. Immunoflourescence. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Buffer
PBS containing 0.02 % sodium azide
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation
Avoid repeated freezing and thawing.
Stock
4 °C/-20 °C
Stockage commentaire
Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
Antigène
SLC22A17
(Solute Carrier Family 22 (Organic Cation Transporter), Member 17 (SLC22A17))
anticorps 1700094C23Rik, anticorps 24p3R, anticorps AU041908, anticorps AW555662, anticorps BOIT, anticorps Boct, anticorps mBOCT, anticorps BOCT, anticorps NGALR, anticorps NGALR2, anticorps NGALR3, anticorps hBOIT, anticorps rBOCT, anticorps solute carrier family 22 member 17, anticorps solute carrier family 22 (organic cation transporter), member 17, anticorps solute carrier family 22, member 17, anticorps SLC22A17, anticorps Slc22a17
Sujet
The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins expressed predominantly in kidney and liver. Each contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2. Transporters of the SLC22 family function in different ways such as uniporters that mediate facilitated diffusion in either direction (OCTs), as anion exchangers (OAT1, OAT3 and URAT1), and as Na(+)/l-carnitine cotransporter (OCTN2). Slc22 family members participate in the absorption and/or excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart. Mutations in the Slc22 family may cause specific diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and may change drug absorption or excretion. Recent studies show the expression of Slc22A17 as receptor for Lipocalin 2 is relatively high in hematopoietic stem cells.Synonyms: BOCT, BOIT, Brain-type organic cation transporter, Solute carrier family 22 member 17