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SLPI anticorps (Center)

SLPI Reactivité: Humain, Souris WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500774
  • Antigène Voir toutes SLPI Anticorps
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    Épitope
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    Humain, Souris
    Hôte
    • 42
    • 12
    • 3
    Lapin
    Clonalité
    • 46
    • 11
    Polyclonal
    Conjugué
    • 24
    • 12
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SLPI est non-conjugé
    Application
    • 46
    • 27
    • 19
    • 11
    • 8
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects Antileukoproteinase (ALP).
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse
    Purification
    Peptide affinity chromatography
    Immunogène
    SLPI antibody was raised against a 17 amino acid peptide from near the center of human SLPI.
    Isotype
    IgG
    Top Product
    Discover our top product SLPI Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Sayers, Brooks, Sayers, Chertov: "Increased secretory leukocyte protease inhibitor (SLPI) production by highly metastatic mouse breast cancer cells." dans: PLoS ONE, Vol. 9, Issue 8, pp. e104223, (2015) (PubMed).

  • Antigène
    SLPI (Secretory Leukocyte Peptidase Inhibitor (SLPI))
    Autre désignation
    Antileukoproteinase (ALP) (SLPI Produits)
    Synonymes
    anticorps ALK1, anticorps ALP, anticorps BLPI, anticorps HUSI, anticorps HUSI-I, anticorps MPI, anticorps WAP4, anticorps WFDC4, anticorps MATN4, anticorps SLPI, anticorps ckpi, anticorps secretory leukocyte peptidase inhibitor, anticorps antileukoproteinase, anticorps SLPI, anticorps Slpi, anticorps LOC102174044
    Sujet
    Secretory leukocyte protease inhibitor (SLPI) is produced at mucosal surfaces, primarily the upper respiratory tract and is thought to play an important role in the antiprotease defense mechanism of the lung. SLPI forms inhibitory complexes with numerous proteolytic enzymes such as neutrophil elastase, and has been shown to possess anti-inflammatory, anti-viral, and antibacterial activities. Its expression in oral epithelial cells is stimulated by HIV-1 gp120, suggesting that SLPI is a component of the oral mucosal response to HIV-1. In peripheral blood monocytes, SLPI can inhibit NF-kB activation by inhibiting IkB degradation in the cytoplasm and competing for NF-kB binding sites in the nucleus. This attenuation of the inflammatory response may also act to suppress liver metastases and other cancer cell invasions, but promote blood-borne metastasis via an invasion-independent pathway.Synonyms: BLPI, HUSI-1, Mucus proteinase inhibitor, Protease inhibitor WAP4, SLPI, Secretory leukocyte protease inhibitor, Seminal proteinase inhibitor, WAP four-disulfide core domain protein 4, WAP4, WFDC4
    ID gène
    6590
    UniProt
    P03973
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