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SPRED1 anticorps (Center)

SPRED1 Reactivité: Humain, Souris, Rat WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN500796
  • Antigène Voir toutes SPRED1 Anticorps
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Épitope
    • 7
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivité
    Humain, Souris, Rat
    Hôte
    • 37
    • 7
    Lapin
    Clonalité
    • 37
    • 7
    Polyclonal
    Conjugué
    • 20
    • 6
    • 5
    • 5
    • 4
    • 4
    Cet anticorp SPRED1 est non-conjugé
    Application
    • 39
    • 34
    • 20
    • 7
    • 6
    • 2
    • 2
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects SPRED1 at center. It is predicted to have no cross-reactivity to Spred2 or Spred3.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, mouse, rat
    Purification
    Peptide affinity chromatography
    Immunogène
    Spred1 antibody was raised against a 20 amino acid peptide near the center of the human Spred1.
    Isotype
    IgG
    Top Product
    Discover our top product SPRED1 Anticorps primaire
  • Indications d'application
    ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS containing 0.02 % sodium azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    SPRED1 (Sprouty-Related, EVH1 Domain Containing 1 (SPRED1))
    Autre désignation
    SPRED1 (SPRED1 Produits)
    Synonymes
    anticorps fb14c08, anticorps fj51c03, anticorps zgc:85707, anticorps wu:fb14c08, anticorps wu:fj51c03, anticorps Xspred1, anticorps Xtspred1, anticorps 5730461F13Rik, anticorps AL024345, anticorps AW047647, anticorps NFLS, anticorps hSpred1, anticorps spred-1, anticorps sprouty-related, EVH1 domain containing 1, anticorps sprouty related EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1, anticorps sprouty related, EVH1 domain containing 1 L homeolog, anticorps SPRED1, anticorps sprouty protein with EVH-1 domain 1, related sequence, anticorps spred1, anticorps SPRED1, anticorps spred1.L, anticorps Bm1_51610, anticorps Spred1
    Sujet
    The Ras-MAP kinase pathway is essential for the differentiation of neuronal cells and myocytes, it is inhibited by Spred1, a member of the Sprouty family of proteins. Spred1 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. Defects in this gene are a cause of neurofibromatosis type 1-like syndrome (NFLS).Synonyms: EVH1/Sprouty domain containing protein, NFLS, Spred-1, Suppressor of Ras/MAPK activation
    ID gène
    161742
    NCBI Accession
    NP_689807
    Pathways
    Positive Regulation of Response to DNA Damage Stimulus
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