Syntaphilin anticorps (Center)
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- Antigène Voir toutes Syntaphilin (SNPH) Anticorps
- Syntaphilin (SNPH)
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Épitope
- Center
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Syntaphilin est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects Syntaphilin.
- Réactivité croisée (Details)
- Species reactivity (tested):Human, mouse, rat
- Purification
- Peptide affinity chromatography
- Immunogène
- Syntaphilin antibody was raised against a 16 amino acid peptide from near the center of human Syntaphilin.
- Isotype
- IgG
- Top Product
- Discover our top product SNPH Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- Syntaphilin (SNPH)
- Autre désignation
- Syntaphilin / SNPH (SNPH Produits)
- Synonymes
- anticorps bA314N13.5, anticorps 6430515A01, anticorps AW045671, anticorps AW556958, anticorps AW743098, anticorps mKIAA0374, anticorps syntaphilin, anticorps SNPH, anticorps Snph
- Sujet
- Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Despite its predicted molecular weight, Syntaphilin usually migrates at higher molecular weight in SDS-PAGE. Multiple isoforms are known to exist.Synonyms: KIAA0374
- ID gène
- 9751
- UniProt
- O15079
- Pathways
- Synaptic Vesicle Exocytosis
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