ARHGEF17 anticorps (Center)

N° du produit ABIN500893

Détail du produit anti-ARHGEF17 anticorps

Antigène: ARHGEF17 (rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17))

Épitope: Center

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ARHGEF17 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects ARHGEF17 / TEM4 at center.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Peptide affinity chromatography

Immunogène: TEM4 antibody was raised against a 18 amino acid peptide near the center of human TEM4.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur ARHGEF17

Antigène: ARHGEF17 (rho Guanine Nucleotide Exchange Factor (GEF) 17 (ARHGEF17))

Autre désignation: ARHGEF17 / TEM4 (ARHGEF17 Produits)

Synonymes: anticorps P164RHOGEF, anticorps TEM4, anticorps p164-RhoGEF, anticorps 8030463K16, anticorps AI428794, anticorps AW558066, anticorps BC035332, anticorps mKIAA0337, anticorps Rho guanine nucleotide exchange factor 17, anticorps Rho guanine nucleotide exchange factor (GEF) 17, anticorps ARHGEF17, anticorps Arhgef17

Sujet: Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.Synonyms: 164 kDa Rho-specific guanine-nucleotide exchange factor, KIAA0337, Rho guanine nucleotide exchange factor 17, Tumor endothelial marker 4, p164-RhoGEF, p164RhoGEF

ID gène: 9828

UniProt: Q96PE2