TMED10 anticorps (Center)

N° du produit ABIN500992

Détail du produit anti-TMED10 anticorps

Antigène: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Épitope: Center

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TMED10 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects TMED10 / TMP21 at Center.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Peptide affinity chromatography

Immunogène: TMP21 antibody was raised against a 18 amino acid peptide from near the center of human TMP21.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 1 - 2 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur TMED10

Antigène: TMED10 (Transmembrane Emp24-Like Trafficking Protein 10 (TMED10))

Autre désignation: TMED10 / TMP21 (TMED10 Produits)

Synonymes: anticorps tmp21, anticorps P24(DELTA), anticorps S31I125, anticorps S31III125, anticorps TMP21, anticorps Tmp-21-I, anticorps p23, anticorps 1110014C03Rik, anticorps Tmp21, anticorps p24delta1, anticorps fe06g04, anticorps wu:fb98e10, anticorps wu:fe06g04, anticorps zgc:85681, anticorps transmembrane p24 trafficking protein 10 L homeolog, anticorps transmembrane p24 trafficking protein 10, anticorps tmed10.L, anticorps TMED10, anticorps Tmed10, anticorps tmed10

Sujet: TMP21 is a ubiquitously expressed protein that is involved in vesicular targeting and protein transport. More recent experiments have shown that it is also a component in the presenilin complex and modulates the γ-secretase but not theεsecretase cleavage activity of the amyloid precursor protein. The presenilin complex is composed of the proteins APH1, nicastrin, and PEN2 in addition to presenilin-1. Together, these proteins cleave the amyloid precursor protein at what is known as the γ and ε-sites and can lead to the accumulation of the Aβ cleavage product that is associated with Alzheimer's disease. Co-immunoprecipitation experiments using antibodies against these proteins also yielded TMP21 indicating that TMP21 may play a role in the regulation of this complex. Suppression of TMP21 expression by siRNA in transfected cells caused increased γ-secretase activity but not ε-secretase activity, and increased Aβ production, demonstrating that TMP21 can modulate γsecretase activity.Synonyms: 21 kDa transmembrane-trafficking protein, S31I125, Transmembrane emp24 domain-containing protein 10, Transmembrane protein Tmp21

ID gène: 10972