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SASS6 anticorps (AbBy Fluor® 750)

SASS6 Reactivité: Humain, Souris, Rat WB, IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 750
N° du produit ABIN5010245
  • Antigène Voir toutes SASS6 Anticorps
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Reactivité
    • 37
    • 17
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    Humain, Souris, Rat
    Hôte
    • 35
    • 2
    Lapin
    Clonalité
    • 37
    Polyclonal
    Conjugué
    • 14
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SASS6 est conjugé à/à la AbBy Fluor® 750
    Application
    • 34
    • 14
    • 12
    • 4
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Humain, Souris, Rat
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SASS6
    Isotype
    IgG
    Top Product
    Discover our top product SASS6 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    SASS6 (Spindle Assembly 6 Homolog (SASS6))
    Autre désignation
    SASS6 (SASS6 Produits)
    Synonymes
    anticorps SAS-6, anticorps SAS6, anticorps 2810453L12Rik, anticorps RGD1306255, anticorps CG15524, anticorps DSAS-6, anticorps DSas-6, anticorps DSas6, anticorps Dmel\\CG15524, anticorps Dsas6, anticorps Sas-6, anticorps Sas6, anticorps dsas-6, anticorps sas6, anticorps wu:fb98c12, anticorps zgc:55668, anticorps SASS6, anticorps sass6.2, anticorps SAS-6 centriolar assembly protein, anticorps Spindle assembly abnormal 6, anticorps spindle assembly 6 homolog L homeolog, anticorps SAS-6 centriolar assembly protein L homeolog, anticorps SASS6, anticorps Sass6, anticorps Sas-6, anticorps sass6.L, anticorps sass6, anticorps sass6.2.L
    Sujet

    Synonyms: HsSAS 6, HsSAS6, MGC119440, SAS 6, SAS6, SASS 6, Spindle assembly 6 homolog C. elegans, Spindle assembly 6 homolog, Spindle assembly abnormal protein 6 homolog, PJA2_HUMAN.

    Background: SAS-6 (spindle assembly abnormal protein 6 homolog, HsSAS-6) is a 657 amino acid protein encoded by the human gene SAS6. SAS-6 is a component of the centrosome that contains one PISA (present in SAS-6) domain. LK4, SAS-6, CPAP and other centriole related proteins are required at different stages of procentriole formation and were associated with different centriolar structures. SAS-6 associates only transiently with nascent procentrioles, whereas CEP135 and CPAP form a core structure within the proximal lumen of both parental and nascent centrioles. SAS-6 is necessary for procentriole formation in human cell lines and is localized asymmetrically next to the centriole at the onset of procentriole formation. SAS-6 levels oscillate during the cell cycle, it is degraded in mitosis starting at anaphase, and it accumulates again at the end of the following G1 phase. The anaphase-promoting complex targets SAS-6 for degradation by the 26S Proteasome, and a KEN box in the C-terminus of SAS-6 is necessary for its degradation. Increased SAS-6 levels promoted the formation of multiple procentrioles forming next to a single centriole.

    ID gène
    163786
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