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Senataxin (SETX) (AA 321-398) anticorps (AbBy Fluor® 750)

SETX Reactivité: Souris WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 750
N° du produit ABIN5010372
  • Antigène Voir toutes Senataxin (SETX) Anticorps
    Senataxin (SETX)
    Épitope
    • 14
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 321-398
    Reactivité
    • 14
    • 11
    • 1
    Souris
    Hôte
    • 23
    • 2
    Lapin
    Clonalité
    • 22
    • 3
    Polyclonal
    Conjugué
    • 8
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AbBy Fluor® 750
    Application
    • 20
    • 12
    • 12
    • 9
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris
    Homologie
    Human,Rat,Dog,Cow,Sheep,Horse
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human Senataxin
    Isotype
    IgG
    Top Product
    Discover our top product SETX Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    Senataxin (SETX)
    Autre désignation
    Senataxin/SETX (SETX Produits)
    Synonymes
    anticorps ALS4, anticorps SETX, anticorps wu:fj92h09, anticorps AOA2, anticorps SCAR1, anticorps bA479K20.2, anticorps Als4, anticorps Sen1, anticorps AW060766, anticorps mKIAA0625, anticorps A130090N03, anticorps A930037J23Rik, anticorps RGD1565575, anticorps senataxin, anticorps SETX, anticorps setx, anticorps Setx
    Sujet

    Synonyms: ALS4, AOA2, SCAR1, bA479K20.2, Probable helicase senataxin, Amyotrophic lateral sclerosis 4 protein, SEN1 homolog, Senataxin, SETX, KIAA0625

    Background: Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation (By similarity). Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI) (By similarity). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

    ID gène
    23064
    UniProt
    Q7Z333
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