Smad1/5 anticorps (pSer463, pSer465) (AbBy Fluor® 750)
-
- Antigène Tous les produits Smad1/5 (SMAD1/5)
- Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
-
Épitope
- pSer463, pSer465
-
Reactivité
- Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp Smad1/5 est conjugé à/à la AbBy Fluor® 750
-
Application
- Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Western Blotting (WB)
- Specificité
- This phosphorylation site is homologous in the listed cross reactive species at the specified location.
- Réactivité croisée
- Souris, Rat
- Homologie
- Human
- Purification
- Purified by Protein A.
- Immunogène
- KLH conjugated synthetic phosphopeptide derived from human Smad1/5 around the phosphorylation site of Ser463/465
- Isotype
- IgG
-
-
- Indications d'application
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Agent conservateur
- ProClin
- Précaution d'utilisation
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Date de péremption
- 12 months
-
- Antigène
- Smad1/5 (SMAD1/5) (Smad1/5 Protein (SMAD1/5))
- Autre désignation
- Smad1/5 + (SMAD1/5 Produits)
- Sujet
-
Synonyms: Smad1 phospho S463/465, Smad1 phospho Ser463/465, p-Smad1 Ser463/465, Mothers against decapentaplegic homolog 1, BSP 1, BSP1, BSP-1, Dwarfin A, DwfA, hSMAD 1, hSMAD1, JV 41, JV4 1, JV4-1, JV41, MAD mothers against decapentaplegic homolog 1, Mad related protein 1, MADH 1, MADH1, Madr 1, MADR1, Mothers against decapentaplegic homolog 1, Mothers against DPP homolog 1, Sma and Mad related protein 1, SMAD 1, SMAD-1, SMAD family member 1, SMAD mothers against DPP homolog 1 Drosophila, Spinal muscular atrophy distal with upper limb predominance, TGF beta signaling protein 1, Transforming growth factor beta signaling protein 1, SMAD1_HUMAN, MAD homolog 1, Mothers against DPP homolog 1, Mad-related protein 1, SMAD family member 1, Smad1, Transforming growth factor-beta-signaling protein 1.
Background: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq].
- ID gène
- 4086, 4090
-