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ATL1 anticorps (AA 201-300) (AbBy Fluor® 750)

ATL1 Reactivité: Souris, Rat WB, IF (cc), IF (p) Hôte: Lapin Polyclonal AbBy Fluor® 750
N° du produit ABIN5010920
  • Antigène Voir toutes ATL1 Anticorps
    ATL1 (Atlastin GTPase 1 (ATL1))
    Épitope
    • 14
    • 10
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    AA 201-300
    Reactivité
    • 34
    • 18
    • 18
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Souris, Rat
    Hôte
    • 46
    • 2
    Lapin
    Clonalité
    • 46
    • 2
    Polyclonal
    Conjugué
    • 15
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ATL1 est conjugé à/à la AbBy Fluor® 750
    Application
    • 37
    • 22
    • 12
    • 12
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
     Réactivité croisée
    Souris, Rat
    Homologie
    Human,Rabbit
    Purification
    Purified by Protein A.
    Immunogène
    KLH conjugated synthetic peptide derived from human SPG3A/Atlastin
    Isotype
    IgG
    Top Product
    Discover our top product ATL1 Anticorps primaire
  • Indications d'application
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Agent conservateur
    ProClin
    Précaution d'utilisation
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Date de péremption
    12 months
  • Antigène
    ATL1 (Atlastin GTPase 1 (ATL1))
    Autre désignation
    SPG3A/Atlastin (ATL1 Produits)
    Synonymes
    anticorps ATL1, anticorps SPG3A, anticorps fj46c01, anticorps wu:fj46c01, anticorps spg3a, anticorps MGC146251, anticorps AD-FSP, anticorps FSP1, anticorps GBP3, anticorps HSN1D, anticorps SPG3, anticorps atlastin1, anticorps 4930435M24Rik, anticorps Adfsp, anticorps Fsp1, anticorps Spg3, anticorps Spg3a, anticorps atlastin, anticorps Atlastin-1, anticorps atlastin GTPase 1, anticorps ATL1, anticorps atl1, anticorps Atl1
    Sujet

    Synonyms: AD FSP, atl1, ATLA1_HUMAN, Atlastin GTPase 1, Atlastin-1, Atlastin1, Brain specic GTP binding protein, Brain-specic GTP-binding protein, FSP1, GBP-3, GBP3, GTP-binding protein 3, Guanine nucleotide-binding protein 3, Guanylate binding protein 3, hGBP3, HSN1D, Spastic paraplegia 3 protein A, SPG 3A, SPG3, SPG3A.

    Background: Atlastins are Golgi-localized, integral membrane proteins that function as GTPases. The Atlastin proteins, also designated SPG3A and guanylate-binding protein 3, comprise a Dynamin superfamily that plays a role in axonal maintenance. Hereditary spastic paraplegia (HSP) is an inherited neurodegenerative disorder that is characterized by retrograde axonal degeneration. HSP primarily affects long corticospinal neurons and causes spastic lower extremity weakness. Spastin, a microtubule (MT)-severing AAA ATPase, is a binding partner of Atlastin that is involved in membrane dynamics. This Spastin/Atlastin binding may be involved in the biochemical pathway that leads to HSP development. Mutations in the Atlastin gene (SPG3A) account for approximately 10 % of all autosomal dominant HSPs, while mutations in the Spastin gene (SPG4) account for almost 40 %.

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