UNC93B1 anticorps (N-Term)

N° du produit ABIN501104

Détail du produit anti-UNC93B1 anticorps

Antigène: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Épitope: N-Term

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp UNC93B1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects Unc93b. The antibody will not cross-react with Unc93a.

Réactivité croisée (Details): Species reactivity (tested):Human, mouse, rat

Purification: Affinity chromatography

Immunogène: Unc93b antibody was raised against a 19 amino acid peptide from near the amino terminus of human Unc93b.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur UNC93B1

Antigène: UNC93B1 (Unc-93 Homolog B1 (UNC93B1))

Autre désignation: UNC93B1 (UNC93B1 Produits)

Synonymes: anticorps UNC93, anticorps IIAE1, anticorps UNC93B, anticorps Unc-93B1, anticorps Unc93b, anticorps unc-93 homolog B1, TLR signaling regulator, anticorps unc-93 homolog B1 (C. elegans), anticorps UNC93B1, anticorps Unc93b1

Sujet: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9, the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity. Multiple isoforms of Unc93a are known to exist.Synonyms: Protein unc-93 homolog B1, UNC-93B, UNC93

ID gène: 81622

NCBI Accession: NP_112192

Pathways: Signalisation TLR, Activation of Innate immune Response, Toll-Like Receptors Cascades