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MAVS anticorps (N-Term)

MAVS Reactivité: Humain, Souris, Rat WB, IF, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN501118
  • Antigène Voir toutes MAVS Anticorps
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Épitope
    • 15
    • 13
    • 8
    • 8
    • 8
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 48
    • 37
    • 3
    • 2
    • 1
    Humain, Souris, Rat
    Hôte
    • 69
    • 7
    Lapin
    Clonalité
    • 71
    • 5
    Polyclonal
    Conjugué
    • 34
    • 6
    • 6
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp MAVS est non-conjugé
    Application
    • 68
    • 37
    • 13
    • 13
    • 11
    • 9
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Specificité
    This antibody detects MAVS at N-term.
    Réactivité croisée (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Purification
    Affinity chromatography
    Immunogène
    VISA antibody was raised against a 13 amino acid peptide from near the amino terminus of human VISA.
    Isotype
    IgG
    Top Product
    Discover our top product MAVS Anticorps primaire
  • Indications d'application
    ELISA. Western blot. Immunohistochemistry on paraffin sections.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Buffer
    PBS, 0.02 % Sodium Azide
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freezing and thawing.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
  • Antigène
    MAVS (Mitochondrial Antiviral Signaling Protein (MAVS))
    Autre désignation
    MAVS (MAVS Produits)
    Synonymes
    anticorps CARDIF, anticorps IPS-1, anticorps IPS1, anticorps VISA, anticorps D430028G21Rik, anticorps Visa, anticorps cardif, anticorps wu:fj20d04, anticorps zgc:158392, anticorps mitochondrial antiviral signaling protein, anticorps MAVS, anticorps Mavs, anticorps mavs
    Sujet
    Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.Synonyms: CARD adapter inducing interferon-beta, Cardif, IPS1, Mitochondrial antiviral-signaling protein, Mitochondrial antiviral-signaling protein, Putative NF-kappa-B-activating protein 031N, VISA, Virus-induced-signaling adapter, nterferon-beta promoter stimulator protein 1
    ID gène
    57506
    NCBI Accession
    NP_065797
    Pathways
    Activation of Innate immune Response, Inositol Metabolic Process, Hepatitis C
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