XAF1 anticorps (Middle Region)
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- Antigène Voir toutes XAF1 Anticorps
- XAF1 (XiAP Associated Factor 1 (XAF1))
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Épitope
- Middle Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp XAF1 est non-conjugé
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Application
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- Specificité
- This antibody detects XAF-1 at Center.
- Réactivité croisée (Details)
- Species reactivity (tested):Human
- Purification
- Affinity chromatography
- Immunogène
- XAF-1 antibody was raised against a synthetic peptide corresponding to 16 amino acids near the middle of human XAF-1.
- Isotype
- IgG
- Top Product
- Discover our top product XAF1 Anticorps primaire
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- Indications d'application
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ELISA. Western blot: 1-2 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Buffer
- PBS containing 0.02 % sodium azide
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freezing and thawing.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Antigène
- XAF1 (XiAP Associated Factor 1 (XAF1))
- Autre désignation
- XAF1 (XAF1 Produits)
- Synonymes
- anticorps BIRC4BP, anticorps HSXIAPAF1, anticorps XIAPAF1, anticorps Fbxo39, anticorps XIAP associated factor 1, anticorps xaf1, anticorps XAF1, anticorps Xaf1
- Sujet
- XAF-1 binds to XIAP, an inhibitor of caspases-3, -7, and -9, and triggers its relocation from the cytosol to the nucleus (1,2). Overexpression of XAF-1 results in the neutralization of XIAP's ability to inhibit cell death (1). XAF-1 is normally expressed in all adult and fetal tissues but was found to be present in very low levels in a variety of cancer cell lines (3). In contrast, XIAP levels have been shown to be high in a majority of cell lines. Low XAF-1 and high basal expression of XIAP may therefore play a critical role in maintaining survival of cancer cell lines (2,3). Both IFN-α2 and IFN-β can induce XAF-1 mRNA in all cells examined but induction of XAF-1 protein (as observed by immunoblot analysis) was seen only in cell lines sensitive to the apoptotic effects of IFNs (4).Synonyms: BIRC4-binding protein, BIRC4BP, XIAP-associated factor 1, XIAPAF1
- ID gène
- 54739
- NCBI Accession
- NP_059993
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