Ectodysplasin A2 Receptor anticorps

N° du produit ABIN501133

Détail du produit anti-Ectodysplasin A2 Receptor anticorps

Antigène: Ectodysplasin A2 Receptor (EDA2R)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ectodysplasin A2 Receptor est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificité: This antibody detects EDA2R / TNFRSF27.

Réactivité croisée (Details): Species reactivity (tested):Human

Purification: Affiinity chromatography

Immunogène: XEDAR antibody was raised against recombinant human XEDAR.

Isotype: IgG

Information d'application

Indications d'application: ELISA. Western blot: 0.5 - 1 μg/mL. Immunohistochemistrry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Buffer: PBS containing 0.02 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Détails sur Ectodysplasin A2 Receptor

Antigène: Ectodysplasin A2 Receptor (EDA2R)

Autre désignation: EDA2R / TNFRSF27 (EDA2R Produits)

Synonymes: anticorps EDA-A2R, anticorps EDAA2R, anticorps TNFRSF27, anticorps XEDAR, anticorps 9430060M22Rik, anticorps Xedar, anticorps RGD1564025, anticorps ectodysplasin A2 receptor, anticorps EDA2R, anticorps Eda2r

Sujet: X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2) (1). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways (2). Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis (3). The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment (3).Synonyms: EDA-A2 receptor, Tumor necrosis factor receptor superfamily member 27, UNQ2448/PRO5727/PRO34080, X-linked ectodysplasin-A2 receptor, XEDAR

ID gène: 60401