ZNRF2 anticorps (AbBy Fluor® 750)

N° du produit ABIN5012805

Détail du produit anti-ZNRF2 anticorps (AbBy Fluor® 750)

Antigène: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNRF2 est conjugé à/à la AbBy Fluor® 750

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human ZNRF2

Isotype: IgG

Information d'application

Indications d'application: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Date de péremption: 12 months

Détails sur ZNRF2

Antigène: ZNRF2 (Zinc and Ring Finger 2 (ZNRF2))

Autre désignation: ZNRF2 (ZNRF2 Produits)

Synonymes: anticorps RNF202, anticorps 1190002C14Rik, anticorps AU044205, anticorps D6Ertd365e, anticorps zgc:152865, anticorps znrf2, anticorps Znrf1, anticorps zgc:171663, anticorps zinc and ring finger 2, anticorps zinc and ring finger 2b, anticorps zinc and ring finger 2a, anticorps ZNRF2, anticorps Znrf2, anticorps znrf2b, anticorps znrf2a

Sujet:

Synonyms: E3 ubiquitin-protein ligase ZNRF2, Protein Ells2, RING finger protein 202, Zinc/RING finger protein 2, Znrf2, ZNRF2_HUMAN.

Background: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). ZNRF2 (zinc and ring finger 2), also known as RNF202, is a 242 amino acid peripheral membrane protein that contains one RING-type zinc finger and localizes to the lysosome, as well as the endosome and the cell junction. Expressed at high levels in brain tissue, ZNRF2 is thought to function as an E3 ubiquitin-protein ligase that may be involved in the establishment and maintenance of neuronal transmission and plasticity. Upon DNA damage, ZNRF2 is subject to phosphorylation, probably by ATR or ATM.

ID gène: 223082

Pathways: Synaptic Membrane