CYLD anticorps (AA 1-230)
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- Antigène Voir toutes CYLD Anticorps
- CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
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Épitope
- AA 1-230
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp CYLD est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Protein A Chromatography
- Immunogène
- A partial length recombinant CYLD protein (amino acids 1-230 ) was used as the immunogen for this antibody.
- Isotype
- IgG
- Top Product
- Discover our top product CYLD Anticorps primaire
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- Indications d'application
- WB: 2-4 μg/mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.05 % BSA, PH 7.4
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C/-20 °C
- Stockage commentaire
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- Antigène
- CYLD (Cylindromatosis (Turban Tumor Syndrome) (CYLD))
- Autre désignation
- CYLD (CYLD Produits)
- Synonymes
- anticorps BRSS, anticorps CDMT, anticorps CYLD1, anticorps CYLDI, anticorps EAC, anticorps MFT, anticorps MFT1, anticorps SBS, anticorps TEM, anticorps USPL2, anticorps 2010013M14Rik, anticorps 2900009M21Rik, anticorps C130039D01Rik, anticorps mKIAA0849, anticorps cyld, anticorps LRRGT00003, anticorps Rp1, anticorps Rp1h, anticorps CYLD lysine 63 deubiquitinase, anticorps cylindromatosis (turban tumor syndrome), a, anticorps CYLD, anticorps Cyld, anticorps cylda
- Sujet
- CYLD (Ubiquitin carboxyl-terminal hydrolase) belongs to peptidase C19 family with 956 amino acids. It is a cytoplasmic protein with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains which function as a deubiquitinating enzyme which specifically cleaves 'Lys-63'-linked polyubiquitin chains and 1 ubiquitin-specific proteases (USP) domain. CYLD plays an important role in the regulation of pathways leading to NF-kappa-B activation, proliferation and differentiation. It also interacts with (via CAP-Gly domain) IKBKG/NEMO (via proline-rich C-terminal region). CYLD is important for the survival of immature natural killer cells whereas it is not required for the maturation of intrathymic natural killer cells. It is detected in fetal brain, testis and skeletal muscle, and at a lower level in adult brain, leukocytes, liver, heart, kidney, spleen, ovary and lung. Isoform 2 is found in all tissues except kidney. CYLD related diseases are multiple familial trichoepithelioma 1 and familial cylindromatosis.
- Poids moléculaire
- 105 kDa
- ID gène
- 1540
- UniProt
- Q9NQC7
- Pathways
- Apoptose, Activation of Innate immune Response
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