FNIP1 anticorps (APC)

N° du produit ABIN5066849

Détail du produit anti-FNIP1 anticorps (APC)

Antigène: FNIP1 (Folliculin Interacting Protein 1 (FNIP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FNIP1 est conjugé à/à la APC

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.,Detects ~130 kDa.

Réactivité croisée: Humain, Souris, Rat

Purification: Peptide Affinity Purified

Immunogène: Synthetic peptide from the mid-protein of Human FNIP1

Isotype: IgG

Information d'application

Indications d'application:

• WB (1:1000)
• ICC/IF (1:100)
• IHC (1:50)
• optimal dilutions for assays should be determined by the user.

Commentaires:

A 1:1000 dilution of ABIN5066849 was sufficient for detection of FNIP1 in 15 μg of mouse kidney cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.09 % sodium azide, Storage buffer may change when conjugated

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: Conjugated antibodies should be stored at 4°C

Détails sur FNIP1

Antigène: FNIP1 (Folliculin Interacting Protein 1 (FNIP1))

Autre désignation: FNIP1 (FNIP1 Produits)

Synonymes: anticorps FNIP1, anticorps DKFZp468P0310, anticorps A730024A03Rik, anticorps AI838773, anticorps AW557298, anticorps folliculin interacting protein 1, anticorps FNIP1, anticorps fnip1, anticorps Fnip1

Sujet: Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).

ID gène: 96459

NCBI Accession: NP_001008738

UniProt: Q8TF40