NBR1 anticorps (AA 2-96)

N° du produit ABIN517601

Détail du produit anti-NBR1 anticorps

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Épitope: AA 2-96

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NBR1 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Mouse monoclonal antibody raised against a partial recombinant NBR1.

Séquence: EPQVTLNVTF KNEIQSFLVS DPENTTWADI EAMVKVSFDL NTIQIKYLDE ENEEVSINSQ GEYEEALKMA VKQGNQLQMQ VHEGHHVVDE APPPV

Réactivité croisée: Humain, Rat

Attributs du produit: Antibody Reactive Against Recombinant Protein.

Immunogène: NBR1 (NP_005890, 2 a.a. ~ 96 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Clone: 6B11

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: In 1x PBS, pH 7.4

Conseil sur la manipulation: Aliquot to avoid repeated freezing and thawing.

Stock: -20 °C

Stockage commentaire: Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

Références pour anticorps anti-NBR1 (ABIN517601)

Jiang, Hara-Kuge, Yamashita, Fujiki: "Peroxin Pex14p is the key component for coordinated autophagic degradation of mammalian peroxisomes by direct binding to LC3-II." dans: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 20, Issue 1, pp. 36-49, (2015) (PubMed).

Dowdle, Nyfeler, Nagel, Elling, Liu, Triantafellow, Menon, Wang, Honda, Pardee, Cantwell, Luu, Cornella-Taracido, Harrington, Fekkes, Lei, Fang, Digan, Burdick, Powers, Helliwell, DAquin, Bastien et al.: "Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. ..." dans: Nature cell biology, Vol. 16, Issue 11, pp. 1069-79, (2014) (PubMed).

Rué, López-Soop, Gelpi, Martínez-Vicente, Alberch, Pérez-Navarro: "Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease." dans: Neurobiology of disease, Vol. 52, pp. 219-28, (2013) (PubMed).

Deosaran, Larsen, Hua, Sargent, Wang, Kim, Lamark, Jauregui, Law, Lippincott-Schwartz, Brech, Johansen, Kim: "NBR1 acts as an autophagy receptor for peroxisomes." dans: Journal of cell science, Vol. 126, Issue Pt 4, pp. 939-52, (2013) (PubMed).

Wong, Bejarano, Rakshit, Lee, Hanson, Zaarur, Phillips, Sherman, Cuervo: "Molecular determinants of selective clearance of protein inclusions by autophagy." dans: Nature communications, Vol. 3, pp. 1240, (2012) (PubMed).

Mardakheh, Auciello, Dafforn, Rappoport, Heath: "Nbr1 is a novel inhibitor of ligand-mediated receptor tyrosine kinase degradation." dans: Molecular and cellular biology, Vol. 30, Issue 24, pp. 5672-85, (2010) (PubMed).

Mardakheh, Yekezare, Machesky, Heath: "Spred2 interaction with the late endosomal protein NBR1 down-regulates fibroblast growth factor receptor signaling." dans: The Journal of cell biology, Vol. 187, Issue 2, pp. 265-77, (2009) (PubMed).

Détails sur NBR1

Antigène: NBR1 (Neighbor of BRCA1 Gene 1 (NBR1))

Autre désignation: NBR1 (NBR1 Produits)

Sujet: Full Gene Name: neighbor of BRCA1 gene 1
Synonyms: 1A1-3B,KIAA0049,M17S2,MIG19

ID gène: 4077

NCBI Accession: NM_005899

Pathways: Autophagy