NUDT1 anticorps (Middle Region)

N° du produit ABIN5514381

Détail du produit anti-NUDT1 anticorps

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Boeuf (Vache), Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NUDT1 est non-conjugé

Application: Western Blotting (WB)

Séquence: WNGFGGKVQE GETIEDGARR ELQEESGLTV DALHKVGQIV FEFVGEPELM

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 86%, Rat: 93%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against 8ODP. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human 8ODP

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NUDT1

Antigène: NUDT1 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Autre désignation: 8ODP (NUDT1 Produits)

Synonymes: anticorps mutT, anticorps nudT1, anticorps MTH1, anticorps Mth1, anticorps 7,8-dihydro-8-oxoguanine triphosphatase, anticorps nudix hydrolase 1, anticorps nudix (nucleoside diphosphate linked moiety X)-type motif 1, anticorps mth1, anticorps Tsp_07498, anticorps nudt1, anticorps 8odp, anticorps NUDT1, anticorps Nudt1

Sujet: Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described.

Alias Symbols: NUDT1, MTH1,

Protein Interaction Partner: ACY1, UBC, DCUN1D1, COPS5, COPS6, CUL1, CUL2, CUL4B, CUL5, CAND1, RNMTL1, NTHL1,

Protein Size: 197

ID gène: 4521

UniProt: P36639