DIO2 anticorps (Middle Region)
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- Antigène Voir toutes DIO2 Anticorps
- DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
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Épitope
- Middle Region
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp DIO2 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- ILLKHVVLLL SRSKSTRGEW RRMLTSEGLR CVWKSFLLDA YKQVKLGEDA
- Purification
- Affinity purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human DIO2
- Top Product
- Discover our top product DIO2 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 23 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- DIO2 (Deiodinase, Iodothyronine, Type II (DIO2))
- Autre désignation
- DIO2 (DIO2 Produits)
- Synonymes
- anticorps 5DII, anticorps D2, anticorps DIOII, anticorps SelY, anticorps TXDI2, anticorps AI324267, anticorps Deio2, anticorps cb684, anticorps DIO2, anticorps dio2-A, anticorps 5dii, anticorps sely, anticorps txdi2, anticorps iodothyronine deiodinase 2, anticorps deiodinase, iodothyronine, type II, anticorps deiodinase, iodothyronine, type 2 L homeolog, anticorps deiodinase, iodothyronine, type 2, anticorps type II iodothyronine deiodinase, anticorps DIO2, anticorps Dio2, anticorps dio2, anticorps dio2.L, anticorps LOC100861220
- Sujet
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The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Alias Symbols: D2, 5DII, SelY, DIOII, TXDI2,
Protein Size: 273 - ID gène
- 1734
- NCBI Accession
- NM_000793, NP_000784
- UniProt
- Q92813
- Pathways
- Hormone Transport, Hormone Activity
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