anticorps DYS, anticorps ELP1, anticorps FD, anticorps IKAP, anticorps IKI3, anticorps TOT1, anticorps IKBKAP, anticorps DKFZp469N1415, anticorps 3110040G09Rik, anticorps 6030413P05, anticorps C78473, anticorps Elp1, anticorps Ikbkap, anticorps elongator complex protein 1, anticorps inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein, anticorps ielongator complex protein 1 S homeolog, anticorps inhibitor of kappa light polypeptide enhancer in B cells, kinase complex-associated protein, anticorps ELP1, anticorps Elp1, anticorps IKBKAP, anticorps elp1.S, anticorps elp1, anticorps Ikbkap
Sujet
The protein encoded by this gene is a scaffold protein and a regulator for three different kinases involved in proinflammatory signaling. The encoded protein can bind NF-kappa-B-inducing kinase and I-kappa-B kinases through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. Alternative splicing results in multiple transcript variants encoding different isoforms.