Urm1 anticorps (N-Term)

N° du produit ABIN5516189

Détail du produit anti-Urm1 anticorps

Antigène: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Urm1 est non-conjugé

Application: Western Blotting (WB)

Séquence: TLPGQEEPWD IRNLLIWIKK NLLKERPELF IQGDSVRPGI LVLINDADWE

Attributs du produit: This is a rabbit polyclonal antibody against URM1. It was validated on Western Blot.

Purification: Affinity purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human URM1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Urm1

Antigène: Urm1 (Ubiquitin Related Modifier 1 (Urm1))

Autre désignation: URM1 (Urm1 Produits)

Synonymes: anticorps RGD1306599, anticorps C9orf74, anticorps 2900073H19Rik, anticorps ubiquitin related modifier 1, anticorps ubiquitin related modifier, anticorps ubiquitin-related modifier, anticorps Ubiquitin-related modifier 1 homolog, anticorps Urm1, anticorps LOC733109, anticorps URM1

Sujet: URM1 acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). URM1 serves as sulfur donor in tRNA 2- thiolation reaction by being thiocarboxylated (-COSH) at its C- terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.

Alias Symbols: C9orf74

Protein Interaction Partner: SEC23IP, DSTN, PTGES3, TXNL1, USP5, XPO1, VCL, PRDX2, PRDX1, ATP6V1A, CTU1, UBC, ASCC2, TBL3, CDK11B, UBA4,

Protein Size: 101

ID gène: 81605

NCBI Accession: NP_112176

UniProt: Q9BTM9